Knowledge is Power
As a leading integrative health clinic, we are committed to the highest standards of peer-reviewed research and clinically-relevant innovations in medical science.
We partner with leading universities, medical institutes, and government agencies to publish breakthrough integrative medicine research in high-impact peer-reviewed journals. Our current collaborations include research at MD Anderson, Columbia University, Cancer Research Laboratory at the Methodist Research Institute, and Indiana University Cancer Center, among others.
- Establishing low‐density lipoprotein apheresis tolerability in patients with prior anaphylactoid reactions to lipoprotein apheresis using magnesium sulfate.
Alexander E, Moriarty P, Wilk B, Eliaz, I.
J Clin Apher 2021 Feb.
Apheresis treatment tolerability had historically been limited by reactions to dextran sulfate in some cases. This study outlines the success of a strategic intervention developed by Isaac Eliaz, MD, at Amitabha Clinic, to prevent apheresis reactions by using magnesium sulfate IV. This approach has proven successful in expanding treatment options to larger patient populations previously unable to receive treatment.
|2.||Lipoprotein apheresis reduces circulating galectin-3 in humans.|
|Eliaz I, Weil E, Dutton JA, McCalley AE, Nolte B, Moriarty PM.|
|J Clin Apher. 2015 Jun 30.|
Plasma galectin-3 (Gal-3) is elevated in, and drives, diverse inflammatory disorders, including cardiovascular diseases, diabetes, and cancer where it promotes tumor growth and metastasis. This study showed for the first time that two apheresis systems performing a procedure where blood is removed, separated, filtered and returned, were able to remove a modest amount of galectin-3.
|3.||Pachymic acid inhibits growth and induces apoptosis of pancreatic cancer in vitro and in vivo by targeting ER stress.|
|Cheng S, Swanson K, Eliaz I, McClintick JN, Sandusky GE, Sliva D.|
|PLoS One. 2015 Apr 27;10(4):e0122270.|
Pachymic acid, a purified triterpene extracted from the medicinal fungus Poria cocos, used in traditional Asian medical systems, was found to have significant activity against chemotherapy-resistant pancreatic cancer, in both cell culture and animal models.
|4.||Honokiol suppresses metastasis of renal cell carcinoma by targeting KISS1/KISS1R signaling.|
|Cheng S, Castillo V, Eliaz I, Sliva D.|
|Int J Oncol. 2015 Jun;46(6):2293-8.|
Honokiol, a bioactive compound isolated from Magnolia officinalis bark, strongly inhibited the process of metastasis, including invasion and colony formation in highly metastatic renal cancer cells.
|5.||A novel form of dichloroacetate therapy for patients with advanced cancer: a report of 3 cases.|
|Khan A, Marier D, Marsden E, Andrews D, Eliaz I.|
|Altern Ther Health Med. 2014 Oct;20 Suppl 2:21-8.|
Oral dichloroacetate (DCA) is a compound currently under investigation as an adjuvant for treatment of various cancers. This case series describes positive clinical results obtained in advanced cancer patients with the use of DCA in an intravenous form, allowing for more effective and less toxic applications.
|6.||Human microbiome and nutrition: untapped clinical potential awaits.|
|Altern Ther Health Med. 2014 Winter;20 Suppl 1:58-60. No abstract available.|
This article describes the importance of the complex community of microorganisms which co-habit the body, with emerging research continuing to uncover profound effects on all aspects of health and development.
|7.||The Role of Galectin-3 as a Marker of Cancer and Inflammation in a Stage IV Ovarian Cancer Patient with Underlying Pro-Inflammatory Comorbidities.|
|Case Rep Oncol. 2013 Jul 3;6(2):343-9.|
This case report describes for the first time the use of galectin-3 blood testing to assess and monitor a cancer patient’s progress.
|8.||Triterpenes from Poria cocos suppress growth and invasiveness of pancreatic cancer cells through the downregulation of MMP-7.|
|Cheng S, Eliaz I, Lin J, Thyagarajan-Sahu A, Sliva D.|
|Int J Oncol. 2013 Jun;42(6):1869-74.|
Triterpenes from P. cocos, a medicinal mushroom widely used in traditional Asian medicine, demonstrated anticancer and anti-invasive effects in human pancreatic cancer cells by downregulating multiple signaling pathways and promoting cell cycle arrest.
|9.||Cold and flu: a pound of prevention.|
|Occup Health Saf. 2012 Nov;81(11):40, 42. No abstract available.|
|.||BreastDefend™ prevents breast-to-lung cancer metastases in an orthotopic animal model of triple-negative human breast cancer.|
|Jiang J, Thyagarajan-Sahu A, Loganathan J, Eliaz I, Terry C, Sandusky GE, Sliva D.|
|Oncol Rep. 2012 Oct;28(4):1139-45.|
Oral administration of a dietary supplement containing medicinal mushrooms, medicinal herbs and biologically active nutritional compounds, was found to suppress tumor growth and breast-to-lung metastasis in a model of human breast cancer cells implanted in mice.
|11.||Synergistic and additive effects of modified citrus pectin with two polybotanical compounds, in the suppression of invasive behavior of human breast and prostate cancer cells.|
|Jiang J, Eliaz I, Sliva D.|
|Integr Cancer Ther. 2013 Mar;12(2):145-52.|
This study showed that when modified citrus pectin was combined with specific breast or prostate formulas, the effects were synergistic, showing greater benefits than either compound alone in inhibiting the metastasis of human breast and prostate cancer cells.
|12.||ProstaCaid inhibits tumor growth in a xenograft model of human prostate cancer.|
|Jiang J, Loganathan J, Eliaz I, Terry C, Sandusky GE, Sliva D.|
|Int J Oncol. 2012 May;40(5):1339-44.|
A polybotanical prostate formula, when given orally to mice implanted with aggressive human hormone refractory (independent) prostate cancer cells, showed significant anticancer activity by suppressing the growth of prostate cancer via modulation of gene expression, without any signs of toxicity.
|13.||Stay healthy on the job this cold & flu season.|
|Occup Health Saf. 2011 Nov;80(11):36-8. No abstract available.|
|14.||Activation of human T-helper/inducer cell, T-cytotoxic cell, B-cell, and natural killer (NK)-cells and induction of natural killer cell activity against K562 chronic myeloid leukemia cells with modified citrus pectin.|
|Ramachandran C, Wilk BJ, Hotchkiss A, Chau H, Eliaz I, Melnick SJ.|
|BMC Complement Altern Med. 2011 Aug 4;11:59.|
MCP was found to activate T-cytotoxic cells and B-cells, and induced significant activation of NK cells, which were effective in inducing cancer cell death.
|15.||Suppression of growth and invasive behavior of human prostate cancer cells by ProstaCaid™: mechanism of activity.|
|Jiang J, Eliaz I, Sliva D.|
|Int J Oncol. 2011 Jun;38(6):1675-82.|
Treatment of highly invasive human hormone refractory (independent) prostate cancer cells with a dietary supplement for prostate health, potently inhibited cancer cell proliferation and reduced metastatic behavior, by downregulating the expression of multiple genes controlling cancer cell behavior.
|16.||The role of modified citrus pectin as an effective chelator of lead in children hospitalized with toxic lead levels.|
|Zhao ZY, Liang L, Fan X, Yu Z, Hotchkiss AT, Wilk BJ, Eliaz I.|
|Altern Ther Health Med. 2008 Jul-Aug;14(4):34-8.|
This study showed Modified Citrus Pectin induced a dramatic decrease in blood serum levels of lead, (161% average change), and a dramatic increase in lead excretion in a 24-hour urine collection, (132% average change), with no toxicity or side effects.
|17.||Integrative medicine and the role of modified citrus pectin/alginates in heavy metal chelation and detoxification–five case reports.|
|Eliaz I, Weil E, Wilk B.|
|Forsch Komplementmed. 2007 Dec;14(6):358-64.|
|This is the first known documentation of evidence of the gradual decrease of total body heavy metal burden following 5 patients over time, using modified citrus pectin (MCP) and/or an MCP/alginate complex, suggesting a correlation with clinical improvement.|
|18.||The effect of modified citrus pectin on urinary excretion of toxic elements.|
|Eliaz I, Hotchkiss AT, Fishman ML, Rode D.|
|Phytother Res. 2006 Oct;20(10):859-64.|
This pilot trial provides the first evidence that oral administration of modified citrus pectin (MCP) significantly increases the urinary excretion of toxic metals in subjects with a ‘normal’ body load of metals. In the first 24 hours of MCP administration the urinary excretion of arsenic increased 130%; on day 6, cadmium showed a significant 150% urinary excretion, with a dramatic 560% increase in lead excretion.